Drug interactions
Hydrocortisone + Nevirapine
Severity: Moderate
Hydrocortisone and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower hydrocortisone exposure, which could reduce glucocorticoid effect. This matters most in patients dependent on replacement therapy, such as adrenal insufficiency.
What this interaction means in plain words
Hydrocortisone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Nevirapine belongs to Anti Virals.
Why it happens
Nevirapine induction of CYP3A4 increases hydrocortisone metabolism.
What to do
Monitor clinical response and for signs of adrenal insufficiency in replacement patients, and increase the hydrocortisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Hydrocortisone with Nevirapine?
MediHelp rates the interaction as moderate. Hydrocortisone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and may lower hydrocortisone exposure, which could reduce glucocorticoid effect. This matters most in patients dependent on replacement therapy, such as adrenal insufficiency.
How serious is the interaction between Hydrocortisone and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and for signs of adrenal insufficiency in replacement patients, and increase the hydrocortisone dose if needed.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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