Drug interactions
Hydrocortisone + Ocrelizumab
Severity: Moderate
Hydrocortisone and Ocrelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ocrelizumab depletes B cells and corticosteroids suppress immune function, so combined use may increase the risk of infection. Short methylprednisolone-type premedication is standard, but prolonged or high-dose steroids add risk.
What this interaction means in plain words
Hydrocortisone and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Ocrelizumab belongs to Central Nervous System.
Why it happens
Additive immunosuppression from B-cell depletion and glucocorticoid effects.
What to do
Use corticosteroids only for premedication or relapse treatment at the lowest effective dose and duration. Monitor for infection and screen for hepatitis B before ocrelizumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ocrelizumab
- Adenovirus types 4 and 7 live + Ocrelizumab Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Ocrelizumab Contraindicated
- Measles mumps and rubella vaccine live + Ocrelizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Ocrelizumab Contraindicated
- Measles vaccine + Ocrelizumab Contraindicated
- Anti-thymocyte + Ocrelizumab Major
Frequently asked questions
Can I take Hydrocortisone with Ocrelizumab?
MediHelp rates the interaction as moderate. Hydrocortisone and Ocrelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ocrelizumab depletes B cells and corticosteroids suppress immune function, so combined use may increase the risk of infection. Short methylprednisolone-type premedication is standard, but prolonged or high-dose steroids add risk.
How serious is the interaction between Hydrocortisone and Ocrelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use corticosteroids only for premedication or relapse treatment at the lowest effective dose and duration. Monitor for infection and screen for hepatitis B before ocrelizumab.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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