Drug interactions
Hydrocortisone + Tiotropium-olodaterol
Severity: Moderate
Hydrocortisone and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone has mineralocorticoid activity that promotes potassium loss, and olodaterol can further lower potassium. Hypokalemia may result, especially with high doses.
What this interaction means in plain words
Hydrocortisone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocortisone belongs to Endocrine; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive hypokalemia from corticosteroid renal potassium wasting and beta2-mediated intracellular shift.
What to do
Monitor serum potassium in patients on systemic hydrocortisone, and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Hydrocortisone with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Hydrocortisone and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone has mineralocorticoid activity that promotes potassium loss, and olodaterol can further lower potassium. Hypokalemia may result, especially with high doses.
How serious is the interaction between Hydrocortisone and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on systemic hydrocortisone, and replace as needed.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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