Drug interactions
Hydromorphone + Rasagiline
Severity: Moderate
Hydromorphone and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rasagiline is a selective MAO-B inhibitor and can lose selectivity at higher doses. Opioid combinations with MAOIs may cause additive CNS depression, hypotension or serotonergic reactions, although hydromorphone has little serotonergic activity.
What this interaction means in plain words
Hydromorphone and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Rasagiline belongs to Central Nervous System.
Why it happens
MAO inhibition may potentiate opioid sedative and hypotensive effects; the mechanism is not fully established.
What to do
Start hydromorphone at a low dose and titrate carefully while monitoring blood pressure, sedation and signs of serotonin toxicity. Avoid rasagiline doses above the recommended range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Frequently asked questions
Can I take Hydromorphone with Rasagiline?
MediHelp rates the interaction as moderate. Hydromorphone and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rasagiline is a selective MAO-B inhibitor and can lose selectivity at higher doses. Opioid combinations with MAOIs may cause additive CNS depression, hypotension or serotonergic reactions, although hydromorphone has little serotonergic activity.
How serious is the interaction between Hydromorphone and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start hydromorphone at a low dose and titrate carefully while monitoring blood pressure, sedation and signs of serotonin toxicity. Avoid rasagiline doses above the recommended range.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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