Drug interactions
Hydroxycarbamide + Trastuzumab
Severity: Moderate
Hydroxycarbamide and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab given with myelosuppressive agents is associated with higher rates of neutropenia and febrile neutropenia. Hydroxyurea adds its own marrow suppression, so infection risk may increase.
What this interaction means in plain words
Hydroxycarbamide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive hematologic toxicity; trastuzumab increases neutropenia when combined with myelosuppressive therapy.
What to do
Monitor neutrophil counts and signs of infection. Delay or reduce hydroxyurea for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Trastuzumab
Frequently asked questions
Can I take Hydroxycarbamide with Trastuzumab?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab given with myelosuppressive agents is associated with higher rates of neutropenia and febrile neutropenia. Hydroxyurea adds its own marrow suppression, so infection risk may increase.
How serious is the interaction between Hydroxycarbamide and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Delay or reduce hydroxyurea for significant neutropenia.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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