Drug interactions
Hydroxycarbamide + Ublituximab
Severity: Moderate
Hydroxycarbamide and Ublituximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents impair immune function, so using them together may raise the risk of infection. Hydroxyurea also causes myelosuppression, and ublituximab causes B-cell depletion.
What this interaction means in plain words
Hydroxycarbamide and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Ublituximab belongs to Miscellaneous.
Why it happens
Additive immunosuppression from myelosuppression (hydroxyurea) and B-cell depletion (ublituximab).
What to do
Monitor for infection and check blood counts regularly. Delay ublituximab or modify therapy in the presence of active infection or marked cytopenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Other interactions of Ublituximab
Frequently asked questions
Can I take Hydroxycarbamide with Ublituximab?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Ublituximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents impair immune function, so using them together may raise the risk of infection. Hydroxyurea also causes myelosuppression, and ublituximab causes B-cell depletion.
How serious is the interaction between Hydroxycarbamide and Ublituximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check blood counts regularly. Delay ublituximab or modify therapy in the presence of active infection or marked cytopenia.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine, Stavudine, Adenovirus types 4 and 7 live. The full list is on the Hydroxycarbamide page.
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