Drug interactions
Hydroxycarbamide + Vinorelbine
Severity: Moderate
Hydroxycarbamide and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow, so used together they can cause deeper or more prolonged neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
What this interaction means in plain words
Hydroxycarbamide and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive myelosuppressive pharmacodynamic effects.
What to do
Monitor complete blood counts regularly and adjust doses or delay cycles according to neutrophil and platelet counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinorelbine
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Vinorelbine?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow, so used together they can cause deeper or more prolonged neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
How serious is the interaction between Hydroxycarbamide and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust doses or delay cycles according to neutrophil and platelet counts.
What other medicines interact with Vinorelbine?
MediHelp also lists interactions of Vinorelbine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Belatacept. The full list is on the Vinorelbine page.
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