Drug interactions
Hydroxychloroquine + Indapamide
Severity: Major
Hydroxychloroquine and Indapamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can prolong the QT interval and cause hypokalemia and hypomagnesemia, which compounds the QT effect of hydroxychloroquine. This raises the risk of torsades de pointes.
What this interaction means in plain words
Hydroxychloroquine and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Additive QT prolongation, with indapamide-induced hypokalemia and hypomagnesemia increasing susceptibility to arrhythmia.
What to do
Monitor serum potassium and magnesium and replace as needed, and obtain an ECG at baseline; consider another antihypertensive or diuretic if QT risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Hydroxychloroquine with Indapamide?
MediHelp rates the interaction as major. Hydroxychloroquine and Indapamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indapamide can prolong the QT interval and cause hypokalemia and hypomagnesemia, which compounds the QT effect of hydroxychloroquine. This raises the risk of torsades de pointes.
How serious is the interaction between Hydroxychloroquine and Indapamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and replace as needed, and obtain an ECG at baseline; consider another antihypertensive or diuretic if QT risk factors are present.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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