Drug interactions
Hydroxychloroquine + Influenza virus vaccine quadrivalent intranasal
Severity: Minor
Hydroxychloroquine and Influenza virus vaccine quadrivalent intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal vaccine is live attenuated, but hydroxychloroquine is only weakly immunomodulatory and is not a usual barrier to live vaccines. The theoretical concerns are altered vaccine response or prolonged vaccine-virus replication, particularly if other immunosuppressants are used.
What this interaction means in plain words
Hydroxychloroquine and Influenza virus vaccine quadrivalent intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Mild immunomodulation by hydroxychloroquine could theoretically affect live vaccine response; no established mechanism.
What to do
Inactivated injectable influenza vaccine is preferred in patients with rheumatic disease; check for other immunosuppressive therapy before choosing the intranasal product.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as minor. Hydroxychloroquine and Influenza virus vaccine quadrivalent intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intranasal vaccine is live attenuated, but hydroxychloroquine is only weakly immunomodulatory and is not a usual barrier to live vaccines. The theoretical concerns are altered vaccine response or prolonged vaccine-virus replication, particularly if other immunosuppressants are used.
How serious is the interaction between Hydroxychloroquine and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inactivated injectable influenza vaccine is preferred in patients with rheumatic disease; check for other immunosuppressive therapy before choosing the intranasal product.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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