Drug interactions
Hydroxychloroquine + Inotuzumab
Severity: Moderate
Hydroxychloroquine and Inotuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin is associated with QT prolongation, and hydroxychloroquine has a similar effect. Combined use increases the risk of clinically important QT prolongation and arrhythmia.
What this interaction means in plain words
Hydroxychloroquine and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation; the mechanism of inotuzumab-related QT effects is not well established.
What to do
Obtain a baseline ECG and electrolytes, then monitor the ECG during inotuzumab therapy. Correct potassium and magnesium, and consider stopping hydroxychloroquine if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Inotuzumab?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Inotuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inotuzumab ozogamicin is associated with QT prolongation, and hydroxychloroquine has a similar effect. Combined use increases the risk of clinically important QT prolongation and arrhythmia.
How serious is the interaction between Hydroxychloroquine and Inotuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, then monitor the ECG during inotuzumab therapy. Correct potassium and magnesium, and consider stopping hydroxychloroquine if the QTc becomes markedly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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