Drug interactions
Hydroxychloroquine + Insulin aspart-insulin aspart protamine
Severity: Moderate
Hydroxychloroquine and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin. Insulin doses may need to be reduced.
What this interaction means in plain words
Hydroxychloroquine and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Probably enhanced insulin sensitivity and reduced insulin degradation; the mechanism is not fully established.
What to do
Monitor blood glucose when starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin. Insulin doses may need to be reduced.
How serious is the interaction between Hydroxychloroquine and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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