Drug interactions
Hydroxychloroquine + Insulin neutral human-insulin isophane protamine human
Severity: Moderate
Hydroxychloroquine and Insulin neutral human-insulin isophane protamine human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin or other antidiabetic drugs. Insulin requirements may fall after it is started.
What this interaction means in plain words
Hydroxychloroquine and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Insulin neutral human-insulin isophane protamine human belongs to Endocrine.
Why it happens
Probably enhanced insulin sensitivity and reduced insulin clearance; the mechanism is not fully established.
What to do
Monitor glucose when starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Warn patients about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human-insulin isophane protamine human
- Ethanol + Insulin neutral human-insulin isophane protamine human Major
- Insulin neutral human-insulin isophane protamine human + Pentamidine Major
- Insulin neutral human-insulin isophane protamine human + Rosiglitazone Major
- Acarbose + Insulin neutral human-insulin isophane protamine human Moderate
- Albiglutide + Insulin neutral human-insulin isophane protamine human Moderate
- Alogliptin + Insulin neutral human-insulin isophane protamine human Moderate
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Insulin neutral human-insulin isophane protamine human?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Insulin neutral human-insulin isophane protamine human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can lower blood glucose and has been associated with hypoglycemia in patients on insulin or other antidiabetic drugs. Insulin requirements may fall after it is started.
How serious is the interaction between Hydroxychloroquine and Insulin neutral human-insulin isophane protamine human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose when starting hydroxychloroquine and reduce the insulin dose if hypoglycemia occurs. Warn patients about hypoglycemia symptoms.
What other medicines interact with Insulin neutral human-insulin isophane protamine human?
MediHelp also lists interactions of Insulin neutral human-insulin isophane protamine human with, for example, Ethanol, Pentamidine, Rosiglitazone. The full list is on the Insulin neutral human-insulin isophane protamine human page.
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