Drug interactions
Hydroxychloroquine + Japanese encephalitis virus vaccine
Severity: Minor
Hydroxychloroquine and Japanese encephalitis virus vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The inactivated Japanese encephalitis vaccine can be given with hydroxychloroquine. Chloroquine has been reported to reduce the response to some vaccines, so a small reduction in immunogenicity is possible, though not well characterised.
What this interaction means in plain words
Hydroxychloroquine and Japanese encephalitis virus vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Antimalarial immunomodulation may slightly diminish antibody response; the mechanism is not firmly established.
What to do
Complete the vaccine schedule before travel with enough lead time; no change to hydroxychloroquine is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Japanese encephalitis virus vaccine?
MediHelp rates the interaction as minor. Hydroxychloroquine and Japanese encephalitis virus vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The inactivated Japanese encephalitis vaccine can be given with hydroxychloroquine. Chloroquine has been reported to reduce the response to some vaccines, so a small reduction in immunogenicity is possible, though not well characterised.
How serious is the interaction between Hydroxychloroquine and Japanese encephalitis virus vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the vaccine schedule before travel with enough lead time; no change to hydroxychloroquine is needed.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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