Drug interactions
Hydroxychloroquine + Mobocertinib
Severity: Major
Hydroxychloroquine and Mobocertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mobocertinib carries a boxed warning for dose-dependent QTc prolongation and torsades de pointes, and hydroxychloroquine also lengthens the QT interval. Using them together increases the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Hydroxychloroquine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Avoid the combination if possible. If it cannot be avoided, reduce the mobocertinib dose per labeling, monitor ECG and electrolytes frequently, and stop if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Mobocertinib?
MediHelp rates the interaction as major. Hydroxychloroquine and Mobocertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mobocertinib carries a boxed warning for dose-dependent QTc prolongation and torsades de pointes, and hydroxychloroquine also lengthens the QT interval. Using them together increases the risk of serious ventricular arrhythmia.
How serious is the interaction between Hydroxychloroquine and Mobocertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it cannot be avoided, reduce the mobocertinib dose per labeling, monitor ECG and electrolytes frequently, and stop if QTc becomes markedly prolonged.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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