Drug interactions
Hydroxychloroquine + Octreotide
Severity: Moderate
Hydroxychloroquine and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Octreotide can cause bradycardia and QT prolongation, and these effects may add to the QT risk of hydroxychloroquine. The overall risk is modest but relevant in patients with heart disease.
What this interaction means in plain words
Hydroxychloroquine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Octreotide belongs to Endocrine.
Why it happens
Additive QT effects, with octreotide-induced bradycardia increasing susceptibility to torsades de pointes.
What to do
Monitor ECG and heart rate when starting or adjusting either drug, and correct electrolyte abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Octreotide
Frequently asked questions
Can I take Hydroxychloroquine with Octreotide?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Octreotide can cause bradycardia and QT prolongation, and these effects may add to the QT risk of hydroxychloroquine. The overall risk is modest but relevant in patients with heart disease.
How serious is the interaction between Hydroxychloroquine and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate when starting or adjusting either drug, and correct electrolyte abnormalities.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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