Drug interactions
Hydroxychloroquine + Romidepsin
Severity: Major
Hydroxychloroquine and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with QT/T-wave changes, and hydroxychloroquine also prolongs the QT interval. The combination may increase arrhythmia risk.
What this interaction means in plain words
Hydroxychloroquine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Check and correct potassium and magnesium before each romidepsin dose and monitor ECG; avoid the combination if a QT-neutral alternative is available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Romidepsin?
MediHelp rates the interaction as major. Hydroxychloroquine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin has been associated with QT/T-wave changes, and hydroxychloroquine also prolongs the QT interval. The combination may increase arrhythmia risk.
How serious is the interaction between Hydroxychloroquine and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before each romidepsin dose and monitor ECG; avoid the combination if a QT-neutral alternative is available.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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