Drug interactions
Hydroxychloroquine + Thiothixene
Severity: Moderate
Hydroxychloroquine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antipsychotics like thiothixene may prolong the QT interval, and hydroxychloroquine has a similar effect. Together they raise the risk of torsades de pointes.
What this interaction means in plain words
Hydroxychloroquine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG, correct electrolyte abnormalities, and monitor QTc; consider a lower-risk antipsychotic in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Thiothixene?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antipsychotics like thiothixene may prolong the QT interval, and hydroxychloroquine has a similar effect. Together they raise the risk of torsades de pointes.
How serious is the interaction between Hydroxychloroquine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolyte abnormalities, and monitor QTc; consider a lower-risk antipsychotic in patients with cardiac risk factors.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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