Drug interactions
Hydroxychloroquine + Tofacitinib
Severity: Minor
Hydroxychloroquine and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tofacitinib is an immunosuppressive JAK inhibitor, whereas hydroxychloroquine has only weak immunomodulatory effects. The combination is used in rheumatoid arthritis and no significant additive infection risk beyond tofacitinib's own is established.
What this interaction means in plain words
Hydroxychloroquine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydroxychloroquine belongs to Musculoskeletal; Tofacitinib belongs to Musculoskeletal.
Why it happens
No established mechanism; slight theoretical additive immunomodulation.
What to do
No change is needed; continue routine monitoring for infection and laboratory parameters on tofacitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Hydroxychloroquine with Tofacitinib?
MediHelp rates the interaction as minor. Hydroxychloroquine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tofacitinib is an immunosuppressive JAK inhibitor, whereas hydroxychloroquine has only weak immunomodulatory effects. The combination is used in rheumatoid arthritis and no significant additive infection risk beyond tofacitinib's own is established.
How serious is the interaction between Hydroxychloroquine and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is needed; continue routine monitoring for infection and laboratory parameters on tofacitinib.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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