Drug interactions
Hydroxychloroquine + Typhoid vaccine live
Severity: Minor
Hydroxychloroquine and Typhoid vaccine live: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) is a live attenuated bacterial strain, and antimalarials such as chloroquine and mefloquine have in vitro activity against it; hydroxychloroquine is not well studied. Reduced vaccine take is theoretically possible, although antibiotic activity of hydroxychloroquine is not established.
What this interaction means in plain words
Hydroxychloroquine and Typhoid vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of vaccine strain viability; not well established for hydroxychloroquine.
What to do
Complete the oral typhoid vaccine series as scheduled; if concern exists, consider the inactivated injectable vaccine instead.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Typhoid vaccine live?
MediHelp rates the interaction as minor. Hydroxychloroquine and Typhoid vaccine live have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral live typhoid vaccine (Ty21a) is a live attenuated bacterial strain, and antimalarials such as chloroquine and mefloquine have in vitro activity against it; hydroxychloroquine is not well studied. Reduced vaccine take is theoretically possible, although antibiotic activity of hydroxychloroquine is not established.
How serious is the interaction between Hydroxychloroquine and Typhoid vaccine live?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete the oral typhoid vaccine series as scheduled; if concern exists, consider the inactivated injectable vaccine instead.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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