Drug interactions
Hydroxyprogesterone caproate + Nevirapine
Severity: Moderate
Hydroxyprogesterone caproate and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may reduce hydroxyprogesterone concentrations and diminish its effect. The clinical impact is predicted rather than documented.
What this interaction means in plain words
Hydroxyprogesterone caproate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4, which metabolizes hydroxyprogesterone caproate.
What to do
Monitor for reduced therapeutic effect and consider an alternative if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Nevirapine?
MediHelp rates the interaction as moderate. Hydroxyprogesterone caproate and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may reduce hydroxyprogesterone concentrations and diminish its effect. The clinical impact is predicted rather than documented.
How serious is the interaction between Hydroxyprogesterone caproate and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced therapeutic effect and consider an alternative if response is inadequate.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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