Drug interactions
Hydroxyprogesterone caproate + Trimipramine
Severity: Minor
Hydroxyprogesterone caproate and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex hormones have been reported to alter tricyclic antidepressant exposure and response. Any effect with injected hydroxyprogesterone caproate is poorly documented and probably small.
What this interaction means in plain words
Hydroxyprogesterone caproate and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible hormonal modulation of hepatic metabolism of the tricyclic; not well established for this progestin.
What to do
No routine change is needed. Watch for altered antidepressant response or increased tricyclic adverse effects after starting the progestin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Hydroxyprogesterone caproate with Trimipramine?
MediHelp rates the interaction as minor. Hydroxyprogesterone caproate and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex hormones have been reported to alter tricyclic antidepressant exposure and response. Any effect with injected hydroxyprogesterone caproate is poorly documented and probably small.
How serious is the interaction between Hydroxyprogesterone caproate and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for altered antidepressant response or increased tricyclic adverse effects after starting the progestin.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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