Drug interactions
Hydroxyurea + Liposomal doxorubicin
Severity: Moderate
Hydroxyurea and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow, so combined use raises the risk of neutropenia, anemia and thrombocytopenia. Patients may need dose reductions or treatment delays.
What this interaction means in plain words
Hydroxyurea and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Liposomal doxorubicin belongs to Oncology.
Why it happens
Additive myelosuppression.
What to do
Check complete blood counts regularly. Reduce doses or delay treatment if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Hydroxyurea and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow, so combined use raises the risk of neutropenia, anemia and thrombocytopenia. Patients may need dose reductions or treatment delays.
How serious is the interaction between Hydroxyurea and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly. Reduce doses or delay treatment if cytopenias develop.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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