Drug interactions
Hydroxyzine + Isoflurane
Severity: Moderate
Hydroxyzine and Isoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine has a recognized risk of QT prolongation and torsades de pointes. Volatile anesthetics can add to this effect and sedation is also additive.
What this interaction means in plain words
Hydroxyzine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive CNS depression.
What to do
Avoid hydroxyzine premedication in patients with long QT, electrolyte disturbance or other QT-prolonging drugs. Monitor the ECG during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoflurane
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Isoflurane?
MediHelp rates the interaction as moderate. Hydroxyzine and Isoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine has a recognized risk of QT prolongation and torsades de pointes. Volatile anesthetics can add to this effect and sedation is also additive.
How serious is the interaction between Hydroxyzine and Isoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid hydroxyzine premedication in patients with long QT, electrolyte disturbance or other QT-prolonging drugs. Monitor the ECG during anesthesia.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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