Drug interactions
Hydroxyzine + Oxazepam
Severity: Moderate
Hydroxyzine and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine, and with oxazepam it increases drowsiness and impairs concentration and coordination. Older adults may develop confusion and falls.
What this interaction means in plain words
Hydroxyzine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from central H1 antagonism and benzodiazepine GABA-A potentiation.
What to do
Use the lowest effective doses and counsel on avoiding driving and alcohol. Reduce one or both doses if over-sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Oxazepam?
MediHelp rates the interaction as moderate. Hydroxyzine and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine, and with oxazepam it increases drowsiness and impairs concentration and coordination. Older adults may develop confusion and falls.
How serious is the interaction between Hydroxyzine and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on avoiding driving and alcohol. Reduce one or both doses if over-sedation occurs.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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