Drug interactions
Hydroxyzine + Triptorelin
Severity: Moderate
Hydroxyzine and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triptorelin, as a GnRH agonist used for androgen deprivation, can prolong the QT interval, and hydroxyzine also has QT-prolonging potential. Taken together, the risk of QT prolongation and torsades de pointes may be greater, especially with other risk factors.
What this interaction means in plain words
Hydroxyzine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Triptorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QT prolongation).
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Reassess the need for hydroxyzine, use the lowest effective dose, and monitor the QTc during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Triptorelin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Triptorelin?
MediHelp rates the interaction as moderate. Hydroxyzine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triptorelin, as a GnRH agonist used for androgen deprivation, can prolong the QT interval, and hydroxyzine also has QT-prolonging potential. Taken together, the risk of QT prolongation and torsades de pointes may be greater, especially with other risk factors.
How serious is the interaction between Hydroxyzine and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Reassess the need for hydroxyzine, use the lowest effective dose, and monitor the QTc during therapy.
What other medicines interact with Triptorelin?
MediHelp also lists interactions of Triptorelin with, for example, Amisulpride, Arsenic trioxide, Bedaquiline. The full list is on the Triptorelin page.
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