Drug interactions
Hydroxyzine + Zuranolone
Severity: Moderate
Hydroxyzine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and hydroxyzine is also sedating, so the combination can increase CNS depression and psychomotor impairment.
What this interaction means in plain words
Hydroxyzine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A modulation and H1 antagonism.
What to do
Reduce the dose of zuranolone or hydroxyzine if sedation occurs, and counsel against driving. Consider a non-sedating alternative to hydroxyzine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Hydroxyzine with Zuranolone?
MediHelp rates the interaction as moderate. Hydroxyzine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and hydroxyzine is also sedating, so the combination can increase CNS depression and psychomotor impairment.
How serious is the interaction between Hydroxyzine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of zuranolone or hydroxyzine if sedation occurs, and counsel against driving. Consider a non-sedating alternative to hydroxyzine.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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