Drug interactions
Ibandronate + Magnesium oxide
Severity: Moderate
Ibandronate and Magnesium oxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium oxide, whether used as a supplement or an antacid, binds oral ibandronate in the gut and can substantially lower its absorption.
What this interaction means in plain words
Ibandronate and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibandronate belongs to Musculoskeletal; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Chelation of ibandronate by magnesium cations in the gastrointestinal tract reduces absorption.
What to do
Take ibandronate fasting with plain water and wait at least 60 minutes before magnesium oxide.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibandronate
- Aluminum hydroxide + Ibandronate Moderate
- Calcium acetate + Ibandronate Moderate
- Calcium carbonate + Ibandronate Moderate
- Calcium chloride + Ibandronate Moderate
- Calcium citrate + Ibandronate Moderate
- Calcium gluconate + Ibandronate Moderate
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Ibandronate with Magnesium oxide?
MediHelp rates the interaction as moderate. Ibandronate and Magnesium oxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium oxide, whether used as a supplement or an antacid, binds oral ibandronate in the gut and can substantially lower its absorption.
How serious is the interaction between Ibandronate and Magnesium oxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take ibandronate fasting with plain water and wait at least 60 minutes before magnesium oxide.
What other medicines interact with Ibandronate?
MediHelp also lists interactions of Ibandronate with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ibandronate page.
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