Drug interactions
Ibrutinib + Nabumetone
Severity: Moderate
Ibrutinib and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and increases bleeding risk, including serious hemorrhage. Adding an NSAID with antiplatelet effects and GI toxicity further raises the chance of bleeding.
What this interaction means in plain words
Ibrutinib and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Nabumetone belongs to Musculoskeletal.
Why it happens
Ibrutinib inhibits BTK-dependent platelet signaling, which is additive to NSAID inhibition of platelet cyclooxygenase.
What to do
Avoid the combination where possible and use paracetamol for analgesia. If needed, monitor for bleeding and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Nabumetone?
MediHelp rates the interaction as moderate. Ibrutinib and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and increases bleeding risk, including serious hemorrhage. Adding an NSAID with antiplatelet effects and GI toxicity further raises the chance of bleeding.
How serious is the interaction between Ibrutinib and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for analgesia. If needed, monitor for bleeding and consider gastroprotection.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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