Drug interactions
Ibrutinib + Piroxicam
Severity: Moderate
Ibrutinib and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, which may be compounded by the antiplatelet and GI-irritant effects of piroxicam. Serious gastrointestinal or other hemorrhage is possible.
What this interaction means in plain words
Ibrutinib and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive impairment of platelet function (BTK inhibition plus COX-1 inhibition) and NSAID-related mucosal injury.
What to do
Avoid the combination where possible, using paracetamol for analgesia instead. If it must be used, monitor for signs of bleeding and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Piroxicam?
MediHelp rates the interaction as moderate. Ibrutinib and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibrutinib impairs platelet function and carries a bleeding risk, which may be compounded by the antiplatelet and GI-irritant effects of piroxicam. Serious gastrointestinal or other hemorrhage is possible.
How serious is the interaction between Ibrutinib and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using paracetamol for analgesia instead. If it must be used, monitor for signs of bleeding and consider gastroprotection.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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