Drug interactions
Ibuprofen + Imidapril
Severity: Moderate
Ibuprofen and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can weaken the antihypertensive effect of ACE inhibitors such as imidapril. Together they can also reduce renal function and raise potassium, particularly in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Ibuprofen and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Imidapril belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins opposes ACE inhibitor effect and reduces glomerular perfusion.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or limit NSAID use to short courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Ibuprofen with Imidapril?
MediHelp rates the interaction as moderate. Ibuprofen and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can weaken the antihypertensive effect of ACE inhibitors such as imidapril. Together they can also reduce renal function and raise potassium, particularly in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Ibuprofen and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Prefer paracetamol or limit NSAID use to short courses.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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