Drug interactions
Ibuprofen + Moxifloxacin
Severity: Moderate
Ibuprofen and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAID use may lower the seizure threshold further in patients receiving a fluoroquinolone. Reports are mainly with other quinolones, and the risk is higher in predisposed patients.
What this interaction means in plain words
Ibuprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolone GABA-A receptor antagonism, possibly potentiated by NSAIDs.
What to do
Avoid in patients with epilepsy or a seizure history and prefer paracetamol. Counsel the patient to report tremor, agitation or convulsions promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Ibuprofen with Moxifloxacin?
MediHelp rates the interaction as moderate. Ibuprofen and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAID use may lower the seizure threshold further in patients receiving a fluoroquinolone. Reports are mainly with other quinolones, and the risk is higher in predisposed patients.
How serious is the interaction between Ibuprofen and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with epilepsy or a seizure history and prefer paracetamol. Counsel the patient to report tremor, agitation or convulsions promptly.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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