Drug interactions
Ibuprofen + Mycophenolate mofetil
Severity: Moderate
Ibuprofen and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise exposure. NSAIDs also add gastrointestinal and renal risk, particularly in transplant recipients on calcineurin inhibitors.
What this interaction means in plain words
Ibuprofen and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide, plus additive gastrointestinal and renal toxicity.
What to do
Monitor renal function, blood counts and gastrointestinal symptoms. Prefer paracetamol where suitable, or use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Ibuprofen with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Ibuprofen and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may compete with mycophenolic acid glucuronide for renal tubular secretion, which could raise exposure. NSAIDs also add gastrointestinal and renal risk, particularly in transplant recipients on calcineurin inhibitors.
How serious is the interaction between Ibuprofen and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, blood counts and gastrointestinal symptoms. Prefer paracetamol where suitable, or use the lowest NSAID dose for the shortest time.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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