Drug interactions
Ibuprofen + Pegaspargase
Severity: Moderate
Ibuprofen and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase can reduce clotting factor synthesis and cause coagulopathy or hypofibrinogenemia. Ibuprofen impairs platelet function, so the combination may raise the risk of hemorrhage.
What this interaction means in plain words
Ibuprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Pegaspargase belongs to Oncology.
Why it happens
Additive effects on hemostasis: asparaginase-related decreased clotting factor synthesis plus NSAID platelet inhibition.
What to do
Avoid NSAIDs during periods of asparaginase-induced coagulopathy or thrombocytopenia where possible; use paracetamol (acetaminophen) instead. Monitor coagulation tests and platelet count.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Ibuprofen with Pegaspargase?
MediHelp rates the interaction as moderate. Ibuprofen and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase can reduce clotting factor synthesis and cause coagulopathy or hypofibrinogenemia. Ibuprofen impairs platelet function, so the combination may raise the risk of hemorrhage.
How serious is the interaction between Ibuprofen and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs during periods of asparaginase-induced coagulopathy or thrombocytopenia where possible; use paracetamol (acetaminophen) instead. Monitor coagulation tests and platelet count.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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