Drug interactions
Ibuprofen + Voriconazole
Severity: Moderate
Ibuprofen and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole raises ibuprofen concentrations, particularly of the S-enantiomer, which may increase NSAID adverse effects such as gastrointestinal bleeding and renal toxicity. The increase is moderate and usually manageable.
What this interaction means in plain words
Ibuprofen and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibuprofen belongs to Musculoskeletal; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9, the main enzyme metabolizing ibuprofen.
What to do
Use the lowest effective ibuprofen dose and monitor for gastrointestinal bleeding, fluid retention and renal function; reduce the dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Ibuprofen with Voriconazole?
MediHelp rates the interaction as moderate. Ibuprofen and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole raises ibuprofen concentrations, particularly of the S-enantiomer, which may increase NSAID adverse effects such as gastrointestinal bleeding and renal toxicity. The increase is moderate and usually manageable.
How serious is the interaction between Ibuprofen and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective ibuprofen dose and monitor for gastrointestinal bleeding, fluid retention and renal function; reduce the dose if adverse effects appear.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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