Drug interactions
Ibuprofen / famotidine + Latanoprost
Severity: Minor
Ibuprofen / famotidine and Latanoprost: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Studies of ophthalmic prostaglandin analogues combined with NSAIDs have given inconsistent results on intraocular pressure. Ibuprofen may blunt the effect of latanoprost in some patients, and famotidine adds no relevant interaction.
What this interaction means in plain words
Ibuprofen / famotidine and Latanoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible pharmacodynamic interference of NSAID prostaglandin synthesis inhibition with prostaglandin analogue activity; the mechanism is not established.
What to do
No empirical adjustment is needed. Check intraocular pressure at routine follow-up if the NSAID is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ibuprofen / famotidine and Latanoprost, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Latanoprost
- Bimatoprost + Latanoprost Moderate
- Latanoprost + Latanoprostene bunod Moderate
- Latanoprost + Tafluprost Moderate
- Latanoprost + Travoprost Moderate
- Aspirin rectal + Latanoprost Minor
- Aspirin + Latanoprost Minor
Frequently asked questions
Can I take Ibuprofen / famotidine with Latanoprost?
MediHelp rates the interaction as minor. Ibuprofen / famotidine and Latanoprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Studies of ophthalmic prostaglandin analogues combined with NSAIDs have given inconsistent results on intraocular pressure. Ibuprofen may blunt the effect of latanoprost in some patients, and famotidine adds no relevant interaction.
How serious is the interaction between Ibuprofen / famotidine and Latanoprost?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Check intraocular pressure at routine follow-up if the NSAID is started or stopped.
What other medicines interact with Latanoprost?
MediHelp also lists interactions of Latanoprost with, for example, Bimatoprost, Latanoprostene bunod, Tafluprost. The full list is on the Latanoprost page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
