Drug interactions
Ibutilide + Quinidine
Severity: Contraindicated
Ibutilide and Quinidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are class I/III antiarrhythmics that prolong repolarization, and ibutilide has a boxed warning for potentially fatal proarrhythmia. Combined use greatly increases the chance of torsades de pointes.
What this interaction means in plain words
Ibutilide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Additive blockade of cardiac potassium channels causing QT prolongation.
What to do
Do not give ibutilide to patients on quinidine; withhold quinidine for an adequate washout period before cardioversion with ibutilide.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Quinidine?
MediHelp rates the interaction as contraindicated. Ibutilide and Quinidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class I/III antiarrhythmics that prolong repolarization, and ibutilide has a boxed warning for potentially fatal proarrhythmia. Combined use greatly increases the chance of torsades de pointes.
How serious is the interaction between Ibutilide and Quinidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give ibutilide to patients on quinidine; withhold quinidine for an adequate washout period before cardioversion with ibutilide.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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