Drug interactions
Ibutilide + Umeclidinium-vilanterol
Severity: Major
Ibutilide and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs repolarization and can cause torsades de pointes. Vilanterol may add to the risk through beta-adrenergic stimulation and a reduction in serum potassium.
What this interaction means in plain words
Ibutilide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization with beta-agonist-induced hypokalemia and sympathetic stimulation.
What to do
Correct potassium and magnesium before ibutilide and monitor the ECG continuously during and after infusion. Avoid giving the long-acting beta-agonist around the time of the infusion where feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Ibutilide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide markedly prolongs repolarization and can cause torsades de pointes. Vilanterol may add to the risk through beta-adrenergic stimulation and a reduction in serum potassium.
How serious is the interaction between Ibutilide and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before ibutilide and monitor the ECG continuously during and after infusion. Avoid giving the long-acting beta-agonist around the time of the infusion where feasible.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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