Drug interactions
Ibutilide + Ziprasidone
Severity: Contraindicated
Ibutilide and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Ziprasidone adds further QT prolongation, so the likelihood of polymorphic ventricular tachycardia rises sharply. The pairing is contraindicated in ziprasidone labeling.
What this interaction means in plain words
Ibutilide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive delay of ventricular repolarization through potassium channel blockade.
What to do
Do not give together. If cardioversion with ibutilide is needed in a patient on ziprasidone, consider a different strategy such as electrical cardioversion.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Ziprasidone?
MediHelp rates the interaction as contraindicated. Ibutilide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Ziprasidone adds further QT prolongation, so the likelihood of polymorphic ventricular tachycardia rises sharply. The pairing is contraindicated in ziprasidone labeling.
How serious is the interaction between Ibutilide and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together. If cardioversion with ibutilide is needed in a patient on ziprasidone, consider a different strategy such as electrical cardioversion.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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