Drug interactions
Idecabtagene vicleucel + Tacrolimus
Severity: Major
Idecabtagene vicleucel and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus is a potent T-cell suppressant and may impair the expansion and activity of CAR-T cells, reducing the efficacy of idecabtagene vicleucel. Combined immunosuppression also raises the risk of infection.
What this interaction means in plain words
Idecabtagene vicleucel and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idecabtagene vicleucel belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Calcineurin inhibition blocks T-cell activation and proliferation, which CAR-T cell function depends on.
What to do
Avoid tacrolimus around CAR-T infusion and during the period of expansion unless it is essential. If immunosuppression is required, coordinate with the treating cell-therapy team and monitor for infection and loss of response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Idecabtagene vicleucel and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Idecabtagene vicleucel
Frequently asked questions
Can I take Idecabtagene vicleucel with Tacrolimus?
MediHelp rates the interaction as major. Idecabtagene vicleucel and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tacrolimus is a potent T-cell suppressant and may impair the expansion and activity of CAR-T cells, reducing the efficacy of idecabtagene vicleucel. Combined immunosuppression also raises the risk of infection.
How serious is the interaction between Idecabtagene vicleucel and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid tacrolimus around CAR-T infusion and during the period of expansion unless it is essential. If immunosuppression is required, coordinate with the treating cell-therapy team and monitor for infection and loss of response.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
