Drug interactions
Idecabtagene vicleucel + Upadacitinib
Severity: Major
Idecabtagene vicleucel and Upadacitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents affect immune function and may increase infection risk. Immunosuppressants may also impair the expansion and activity of CAR T cells.
What this interaction means in plain words
Idecabtagene vicleucel and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idecabtagene vicleucel belongs to Oncology; Upadacitinib belongs to Musculoskeletal.
Why it happens
Additive immunosuppression, with possible suppression of CAR T-cell expansion and function.
What to do
Avoid upadacitinib around leukapheresis and CAR T infusion unless clearly needed. Monitor for infection and CAR T response if immunosuppression is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Other interactions of Idecabtagene vicleucel
Frequently asked questions
Can I take Idecabtagene vicleucel with Upadacitinib?
MediHelp rates the interaction as major. Idecabtagene vicleucel and Upadacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents affect immune function and may increase infection risk. Immunosuppressants may also impair the expansion and activity of CAR T cells.
How serious is the interaction between Idecabtagene vicleucel and Upadacitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid upadacitinib around leukapheresis and CAR T infusion unless clearly needed. Monitor for infection and CAR T response if immunosuppression is required.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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