Drug interactions
Idelalisib + Isoniazid
Severity: Major
Idelalisib and Isoniazid: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is metabolized by aldehyde oxidase and CYP3A, and it carries serious hepatotoxicity risk. Isoniazid is itself hepatotoxic and may modestly raise idelalisib exposure, so the combined liver injury risk is of concern.
What this interaction means in plain words
Idelalisib and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Additive hepatotoxicity, plus possible modest CYP3A4 inhibition by isoniazid raising idelalisib exposure.
What to do
Monitor ALT and AST closely, more often than usual at the start of therapy. Withhold idelalisib or isoniazid for significant transaminase elevations.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoniazid
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Isoniazid?
MediHelp rates the interaction as major. Idelalisib and Isoniazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is metabolized by aldehyde oxidase and CYP3A, and it carries serious hepatotoxicity risk. Isoniazid is itself hepatotoxic and may modestly raise idelalisib exposure, so the combined liver injury risk is of concern.
How serious is the interaction between Idelalisib and Isoniazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT and AST closely, more often than usual at the start of therapy. Withhold idelalisib or isoniazid for significant transaminase elevations.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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