Drug interactions
Idelalisib + Ketamine
Severity: Moderate
Idelalisib and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and can raise ketamine exposure, especially with oral ketamine. This may prolong sedation, dissociative effects and cardiovascular stimulation.
What this interaction means in plain words
Idelalisib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Ketamine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated ketamine N-demethylation.
What to do
Use lower ketamine doses with oral administration and monitor sedation, blood pressure and psychotomimetic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Ketamine?
MediHelp rates the interaction as moderate. Idelalisib and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and can raise ketamine exposure, especially with oral ketamine. This may prolong sedation, dissociative effects and cardiovascular stimulation.
How serious is the interaction between Idelalisib and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower ketamine doses with oral administration and monitor sedation, blood pressure and psychotomimetic effects.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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