Drug interactions
Idelalisib + Ulipristal
Severity: Moderate
Idelalisib and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may substantially raise ulipristal concentrations. This could increase adverse effects.
What this interaction means in plain words
Idelalisib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Idelalisib inhibits CYP3A4, reducing ulipristal metabolism.
What to do
Prefer a copper intrauterine device or levonorgestrel for emergency contraception. If ulipristal is used, monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Ulipristal?
MediHelp rates the interaction as moderate. Idelalisib and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and may substantially raise ulipristal concentrations. This could increase adverse effects.
How serious is the interaction between Idelalisib and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a copper intrauterine device or levonorgestrel for emergency contraception. If ulipristal is used, monitor for adverse effects.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Cisapride, Dihydroergotamine. The full list is on the Idelalisib page.
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