Drug interactions
Idelalisib + Venlafaxine
Severity: Moderate
Idelalisib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor. Venlafaxine is mainly metabolized by CYP2D6 with a minor CYP3A4 role, so the increase in exposure is likely modest but may raise venlafaxine-related adverse effects.
What this interaction means in plain words
Idelalisib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of venlafaxine.
What to do
Monitor blood pressure, heart rate and signs of serotonergic toxicity, and reduce the venlafaxine dose if adverse effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Venlafaxine?
MediHelp rates the interaction as moderate. Idelalisib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor. Venlafaxine is mainly metabolized by CYP2D6 with a minor CYP3A4 role, so the increase in exposure is likely modest but may raise venlafaxine-related adverse effects.
How serious is the interaction between Idelalisib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and signs of serotonergic toxicity, and reduce the venlafaxine dose if adverse effects develop.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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