Drug interactions
Idelalisib + Zolpidem
Severity: Major
Idelalisib and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib, a strong CYP3A inhibitor, can increase zolpidem concentrations and prolong or intensify sedation and psychomotor impairment.
What this interaction means in plain words
Idelalisib and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Zolpidem belongs to Central Nervous System.
Why it happens
Strong inhibition of CYP3A4, the main metabolic pathway of zolpidem, reducing its clearance.
What to do
Avoid if possible; otherwise start with the lowest zolpidem dose and monitor for oversedation and next-day impairment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Zolpidem?
MediHelp rates the interaction as major. Idelalisib and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib, a strong CYP3A inhibitor, can increase zolpidem concentrations and prolong or intensify sedation and psychomotor impairment.
How serious is the interaction between Idelalisib and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise start with the lowest zolpidem dose and monitor for oversedation and next-day impairment.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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