Drug interactions
Ifosfamide + Iloperidone
Severity: Minor
Ifosfamide and Iloperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is mainly a substrate of CYP3A4 and CYP2D6 with weak CYP3A inhibition, so any effect on ifosfamide is likely small. The clinical significance is doubtful.
What this interaction means in plain words
Ifosfamide and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ifosfamide belongs to Oncology; Iloperidone belongs to Central Nervous System.
Why it happens
Weak, possibly time-dependent CYP3A4 inhibition by iloperidone may slightly alter ifosfamide metabolism.
What to do
No dose adjustment is needed; monitor routinely for ifosfamide efficacy and neurotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Ifosfamide with Iloperidone?
MediHelp rates the interaction as minor. Ifosfamide and Iloperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iloperidone is mainly a substrate of CYP3A4 and CYP2D6 with weak CYP3A inhibition, so any effect on ifosfamide is likely small. The clinical significance is doubtful.
How serious is the interaction between Ifosfamide and Iloperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor routinely for ifosfamide efficacy and neurotoxicity.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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