Drug interactions
Ifosfamide + Itraconazole
Severity: Moderate
Ifosfamide and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide requires CYP3A4 activation but CYP3A4 also forms neurotoxic and nephrotoxic metabolites. Itraconazole may alter the balance of active and toxic metabolites, with uncertain effects on efficacy and toxicity.
What this interaction means in plain words
Ifosfamide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4, altering ifosfamide bioactivation and the formation of toxic metabolites.
What to do
Monitor for reduced response and for neurotoxicity or nephrotoxicity. Consider an alternative antifungal such as one without strong CYP3A4 inhibition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Itraconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Itraconazole?
MediHelp rates the interaction as moderate. Ifosfamide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide requires CYP3A4 activation but CYP3A4 also forms neurotoxic and nephrotoxic metabolites. Itraconazole may alter the balance of active and toxic metabolites, with uncertain effects on efficacy and toxicity.
How serious is the interaction between Ifosfamide and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced response and for neurotoxicity or nephrotoxicity. Consider an alternative antifungal such as one without strong CYP3A4 inhibition.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
