Drug interactions
Ifosfamide + Lomitapide
Severity: Moderate
Ifosfamide and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ifosfamide is a weak CYP3A4 inhibitor and lomitapide is a CYP3A4 substrate, so lomitapide exposure could rise modestly. This may increase gastrointestinal effects and hepatotoxicity risk.
What this interaction means in plain words
Ifosfamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Lomitapide belongs to Cardiovascular.
Why it happens
Possible weak CYP3A4 inhibition by ifosfamide reduces lomitapide clearance.
What to do
Monitor liver enzymes and tolerability, and keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Ifosfamide with Lomitapide?
MediHelp rates the interaction as moderate. Ifosfamide and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ifosfamide is a weak CYP3A4 inhibitor and lomitapide is a CYP3A4 substrate, so lomitapide exposure could rise modestly. This may increase gastrointestinal effects and hepatotoxicity risk.
How serious is the interaction between Ifosfamide and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and tolerability, and keep the lomitapide dose within the labeled limit for weak CYP3A4 inhibitors.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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