Drug interactions
Ifosfamide + Peginterferon alfa 2b
Severity: Moderate
Ifosfamide and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can suppress bone marrow, so combined use may cause deeper or more prolonged neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
What this interaction means in plain words
Ifosfamide and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ifosfamide belongs to Oncology; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Additive myelosuppression through pharmacodynamic synergism.
What to do
Monitor complete blood counts regularly during combined therapy. Reduce doses or delay treatment if significant cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ifosfamide and Peginterferon alfa 2b, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Peginterferon alfa 2b
Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Frequently asked questions
Can I take Ifosfamide with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Ifosfamide and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can suppress bone marrow, so combined use may cause deeper or more prolonged neutropenia, anemia and thrombocytopenia. This raises the risk of infection and bleeding.
How serious is the interaction between Ifosfamide and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly during combined therapy. Reduce doses or delay treatment if significant cytopenias develop.
What other medicines interact with Peginterferon alfa 2b?
MediHelp also lists interactions of Peginterferon alfa 2b with, for example, Aldesleukin, Deferiprone, Pexidartinib. The full list is on the Peginterferon alfa 2b page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
