Drug interactions
Ifosfamide + Tazemetostat
Severity: Minor
Ifosfamide and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and ifosfamide is a substrate with possible weak inhibitory effects. Any change in exposure is probably small, but ifosfamide activation could change slightly.
What this interaction means in plain words
Ifosfamide and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ifosfamide belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Weak CYP3A4 induction by tazemetostat may modestly alter ifosfamide metabolism.
What to do
No dose change is usually needed. Monitor for efficacy and toxicity of both drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ifosfamide
- Adenovirus types 4 and 7 live + Ifosfamide Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine Contraindicated
- Ifosfamide + Measles mumps and rubella vaccine live Contraindicated
- Ifosfamide + Measles mumps rubella and varicella vaccine live Contraindicated
- Ifosfamide + Measles vaccine Contraindicated
- Ifosfamide + Rotavirus oral vaccine live Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ifosfamide with Tazemetostat?
MediHelp rates the interaction as minor. Ifosfamide and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, and ifosfamide is a substrate with possible weak inhibitory effects. Any change in exposure is probably small, but ifosfamide activation could change slightly.
How serious is the interaction between Ifosfamide and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for efficacy and toxicity of both drugs.
What other medicines interact with Ifosfamide?
MediHelp also lists interactions of Ifosfamide with, for example, Adenovirus types 4 and 7 live, Measles mumps and rubella vaccine, Measles mumps and rubella vaccine live. The full list is on the Ifosfamide page.
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